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Inhalation Effects On Body Systems Table

   

Nitrous oxide

Halothane

Methoxyflurane

Enflurane

Isoflurane

Desflurane

Seveoflurane

Cardiovascular

  Blood Pressure

N/C

  Heart Rate

N/C

N/C or

N/C

  SVR

N/C

N/C

N/C

  Cardiac output1

N/C

N/C

N/C or

Respiratory

  Tidal volume

  Resp Rate

  PaCO2

     Resting

N/C

     Challenge

Cerebral

  Blood flow

  ICP

  Cerebral
  metabolic rate2

  Seizures

Neuromuscular

  Nondepolarizing
  blockade3

Renal

  RBF

  GFR

?

?

  Urinary output

?

?

Hepatic

  Blood flow

Metabolism4

0.004%

15-20%

50%

2-5%

0.2%

<0.1%

2-3%

1Controlled ventilation
2CMRO2 would increase with enflurane-induced seizure
3Depolarizing blockade is possibly also prolonged by these agents, but this is usually not clinically significant
4Percentage of absorbed anesthetic undergoing metabolism
N/C = no change; ? = uncertain
Morgan & Mikhail, 2nd Edition. Clinical Anesthesiology. 1996, pg.118.


Last Updated 04/10/00 12:26:57 PM
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